Simian Crease or Single Palmar Crease

                                

The hand I drew on the left has normal horizontal creases. The right hand has one horizontal crease called the “simian crease”, but more appropriately known as the Single Palmar Crease. When doing our Newborn Examination, we will be checking the extremities for creases. This sign can be normal or associated with:

• Down syndrome
• Aarskog syndrome
• Cohen syndrome
• Fetal alcohol syndrome
• Trisomy 13
• Rubella syndrome
• Turner syndrome
• Klinefelter syndrome
• Pseudohypoparathyroidism
• Gonadal dysgenesis – Swyer syndrome
• Cri du chat syndrome